The five free starters

You do not need the Gacha to get started. Five Pokémon are free, and three of them unlock by simply progressing through Classic mode:

PokémonTypeHow to get itWhat its shots do
PikachuElectricAvailable from the startLightning chains between nearby enemies
CharmanderFireAvailable from the startCan burn enemies
SquirtleWaterBeat the Mt. Moon boss (floor 2)Knocks enemies back
BulbasaurGrassBeat the Pokémon Tower boss (floor 3)Shots pierce through enemies
EeveeNormalBeat Mewtwo (floor 5)Plain shots, no type effect

Base stats of the two starters you have from the beginning, from the in-game Pokédex:

PokémonHealthDamageFire rateSpeedLuck
Pikachu33.54.3/s4.21
Charmander34.23.5/s3.90

Which one first? Pikachu’s chain lightning is the friendliest pick for crowded rooms, while Charmander’s burn helps against bosses and the Bug-heavy first floor. Once you have both, bring them together: between Electric and Fire you hit most early enemies for at least normal damage.

How the team of three works

A run uses a team of up to three Pokémon, and you switch between them with 1, 2 and 3. Out of combat switching is free; in combat the Pokémon you switch out rests for 8 seconds before it can come back.

  • Health and items are shared. Every heart and every item you pick up belongs to the whole team.
  • Type, stats and shot effect change with the Pokémon you switch to.
  • Type matchups apply both ways. Your shots deal ×1.5 to enemies weak to your type, and enemies of a type you are weak to hit you harder.

That makes team building simple: pick three Pokémon whose types cover each other’s weaknesses, and switch to the right one for each floor and boss. The type chart lists the matchups, and the floors guide shows which enemy types each floor throws at you.

Levels and evolution

Pokémon level up during a run by defeating enemies, and bosses give far more XP. Team members on the bench get 35% of the XP (70% with Exp. Share).

  • Each level adds +0.8% damage, +0.4% fire rate and +0.2% speed, and heals half a heart.
  • Evolution is automatic at level 14 and 32, or level 20 for lines with only two stages. Rare Candy and evolution stones also evolve a Pokémon.
  • Max level is 60. Levels reset when the run ends.
  • Shinies get a stat bonus over the normal form.

Stats

Each Pokémon has its own set of stats, which you can see on the stats screen (Tab) during a run:

StatWhat it does
HealthYour starting hearts
DamageDamage per shot
Fire rateShots per second
DPSDamage × shots per second, the best single number for comparing Pokémon
RangeHow far shots travel
SpeedMovement speed
LuckBetter drops, and stronger item tiers appear earlier (each point brings them two floors sooner)
The in-run stats panel listing damage, fire rate, range, shot speed, speed and luck
The stats panel (Tab) during a run.

Items change these stats for the whole run, so a Pokémon with low base damage can still carry a run with the right items.

Rarities and regions

Every Pokémon has a rarity, Common, Rare, Epic or Legendary, and belongs to a region. The region decides which Gacha banner it comes from, and rarity decides how likely you are to pull it. Shiny versions are rare variants of the same Pokémon.

Mega Pokémon (37 of them) are a separate group. Their banner only opens after you defeat Armored Mewtwo on floor 30, and they are pulled with Mega Tickets rather than Tokens. See unlocks and Gacha.

What are the starters in PokéIsaac?

Pikachu and Charmander are available from the start. Squirtle unlocks when you beat the Mt. Moon boss (floor 2), Bulbasaur when you beat the Pokémon Tower boss (floor 3), and Eevee when you beat Mewtwo (floor 5).

How many Pokémon are in PokéIsaac?

The developer's launch post lists 971 Pokémon and 37 Mega Pokémon, so 1,008 playable forms in total. Shiny versions exist on top of that.

How do I get more Pokémon?

Every Pokémon other than the five starters comes from the Gacha. Each region has its own banner, and pulls are paid with Tokens earned by playing with an account. See the unlocks and Gacha guide.

Do my three Pokémon have separate health?

No. The team shares one health bar and one set of items. Switching changes your type, stats and shot effect, not your health.